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Many people who receive B12 shots for weight loss notice they feel more motivated to exercise, experience better metabolic function, and see gradual improvements in fat loss

(12(4)) doi:10.3390/children12040442

A 12-week randomized trial demonstrated: Average weight loss of 2.6 kg in AOD-9604 group (1 mg/day) versus 0.8 kg in placebo group Preferential reduction in abdominal and visceral fat deposits No adverse effects on carbohydrate metabolism or insulin sensitivity Non-dose-dependent effects, with higher doses (10 mg/day) producing less weight loss than lower doses However, a subsequent 24-week Phase III trial with 502 subjects incorporating intensive diet and exercise showed no statistically significant weight loss compared to placebo, leading to development termination in 2007

It is not approved for human or animal use and must not be administered outside controlled in-vitro research environments